Wednesday, July 20, 2022

Monkeypox in Chicago

Can Chicago slow the spread of monkeypox?

Fatigue from the COVID-19 pandemic and a shortage of monkeypox vaccines are raising questions over whether the spread of the virus can be contained.

By Courtney Kueppers

Wednesday, July 20, 11:40 a.m. CT

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This 2003 electron microscope image made available by the Centers for Disease Control and Prevention shows mature, oval-shaped monkeypox virions, left, and spherical immature virions, right.

This 2003 electron microscope image made available by the Centers for Disease Control and Prevention shows mature, oval-shaped monkeypox virions, left, and spherical immature virions, right. Cynthia S. Goldsmith, Russell Regner / CDC via Associated Press


The amount of people waiting for a monkeypox vaccine outside Test Positive Aware Network in Edgewater on Monday quickly outnumbered the 100 doses the nonprofit had available.

Standing in the heat, people who learned they wouldn’t get a shot tried to help one another out by passing around phones to share social media posts and texts about where else they may be able to find a vaccine, said a local writer and artist who goes by the name Kal Jazeera, who called Howard Brown Health Center from the line to see if he could get an appointment.

TPAN CEO Kara Eastman said the nonprofit was prepared for high demand, but the level of turnout was “overwhelming.”

The frustrating scavenger hunt for a vaccine comes as monkeypox cases near 200 in Chicago. The rare disease that can lead to a rash is spread primarily through skin-to-skin contact or prolonged intimate contact like kissing, cuddling and sex. The virus began spreading internationally this year and has now been reported in most major U.S. cities. In Chicago, like elsewhere, “most, but not all” of the cases have been reported in gay and bisexual men, or other men who have sex with men, Dr. Allison Arwady said, but stressed that anyone can get monkeypox.

While the overall cases remain low compared to the COVID-19 outbreak, Dr. Anthony Fauci, the country’s top medical official, warned over the weekend that “we have to act like it will have the capability of spreading much more widely than it’s spreading right now.” In Chicago, vaccines have been made available to those most at risk of being exposed to the virus, but demand has far outpaced supply.

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“The severity and the concern and urgency to get vaccinated has really come up very quickly, because it got close to home really fast,” Kal Jazeera said by phone Tuesday afternoon. “I currently know one person with monkeypox and I know about eight to 10 people who have been exposed.”

As of Tuesday, Chicago has received and distributed about 5,000 doses of the monkeypox vaccine, Jynneos, with approximately 15,000 more doses expected to start arriving as early as this week.

But Arwady, the city’s top doctor, acknowledged in a weekly Facebook Live event on Tuesday that even 15,000 doses isn’t enough.

“Many many more people would like to get this vaccine than we have available for,” she said. “As vaccine supply increases, I expect this will evolve and we will likely recommend it to more individuals.”

Here’s how the city is prioritizing who is able to get the two-dose vaccine at this time. It is not recommended for the general public, including men who have sex with men but don’t have other listed risk factors:

  • If you have had close physical contact or were intimate with someone who has been diagnosed with monkeypox.

  • If you are gay, bisexual or a man who has sex with men and have had sexual contact with other men in a social venue or otherwise have had multiple anonymous partners and therefore may not be able to adequately contact trace.

Arwady said the low number of vaccines available is, in part, because of the infrequency of monkeypox outbreaks in the United States.

“Because MPV is really rare, it’s not like there’s lots and lots of this vaccine just sitting on the shelf, your doctor does not just have it in their office, your pharmacist does not have it on the shelf,” she said, adding that the vaccines available have come from the Strategic National Stockpile maintained by the federal government in case of disease outbreaks.

Dr. Anu Hazra of Howard Brown Health Center said the nonprofit LGBTQ health care provider has been “inundated with calls” — hearing from as many as 200 people a day looking for testing or a vaccine.

“What concerns me is how can we tamp down transmission?” Hazra said. “A lot of us talked about how ‘COVID zero’ is sort of an impossible goal, but monkeypox zero should be very much possible. We have the tools to stop it.”

In addition to testing and vaccines, Hazra is recommending that people consider tightening their sexual networks. As a sexual health doctor, he said he will never tell people to stop having sex, but he said it’s important to think carefully about sexual interactions right now and to not have sex if you’re experiencing symptoms.

People diagnosed with monkeypox tend to experience flu-like symptoms, followed by a rash that can look like pimples or blisters. While there are no known deaths from the illness, for some the lesions can be quite painful, officials said.

“I worry about symptom and pain control with monkeypox,” Hazra said. “Just because it doesn’t have the same case fatality rate or whatnot as COVID-19 doesn’t make it any less important.”

While officials have learned a lot in the last two years about responding to public health crises, COVID has also put a strain on health care systems and has highlighted the ways bureaucracy can slow down response. As the monkeypox outbreak emerges amid the still-ongoing pandemic, it’s met by a system that has been highly tested.

“I feel like everyone is tired. I mean, the general public is tired. Health care workers are tired, public health officials are tired,” Hazra said. “So I think all of that also is in the background here.”

Chicago is not the only city where demand has outpaced supply. In New York, where there are more than 500 cases of monkeypox as of Tuesday, soaring demand for the vaccine caused the appointment system to crash.

The frustrations came as the federal government announced additional steps to respond to the outbreak, including providing more monkeypox vaccines and a goal to expand testing.

Anyone who thinks they may have been exposed to monkeypox or who is experiencing an unusual rash is urged to reach out to their health care provider. For those without a primary care doctor, Arwady said publicly people can call the Department of Public Health at 312-746-4835 to be connected to care. However, WBEZ called the number on two different occasions and both times, operators were unsure about directing questions about monkeypox.

TPAN will offer vaccines again next Monday afternoon. For those who plan to come out, Eastman, the CEO, said “be prepared to be patient, but we will make it as smooth as possible.”

The Associated Press contributed to this report.

Courtney Kueppers is a digital producer/reporter at WBEZ. Follow her @cmkueppers.

July 20, 2022: Outbreak Alert Monkeypox

Outbreak Alerts

Monkeypox

Editor: Alyson Browett, MPH

Contributors: Christina Potter, MSPH, Eric Toner, MD, Rachel Vahey, MHS, and Lane Warmbrod, MS, MPH

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Additional Monkeypox Resources

Recent Outbreaks Update as of July 19, 2022 at 3pm EDT

As of 5pm EDT on July 19, there were 14,511 cumulative confirmed cases of monkeypox in 70 countries, territories, and areas, according to the US CDC.* We expect the global cumulative incidence to surpass 15,000 in the next 1-2 days, 11 weeks after the first case in the current outbreak was reported.

A majority of the confirmed cases continue to be reported in European countries, with Spain (3,125), the UK (2,137), and Germany (2,033) making up the 1st, 2nd, and 4th spots, respectively. This week, the US moved into 3rd position, reporting 2,107 confirmed cases, 2.27 times the number reported this time last week. No deaths have been reported in countries not historically reporting monkeypox, while 5 deaths have been reported in African countries.

Based on data from Global.health,** Our World In Data shows a 7-day average of 473 daily confirmed cases as of July 19. The 7-day rolling average of daily confirmed cases appears to have peaked at 537 on July 13 but appears to be leveling out.

*The total number includes 14,268 cases in 64 countries not historically reporting monkeypox cases and 243 cases in 6 countries historically reporting monkeypox cases. The CDC map only includes cases confirmed as monkeypox virus or orthopoxvirus through laboratory testing and are year-to-date totals.

**Global.health data only include countries that have not historically reported monkeypox cases.

WHO EMERGENCY COMMITTEE With many experts expressing concern that the confirmed number of cases likely is an undercount and that the window is closing to contain the global monkeypox outbreak, the WHO Emergency Committee is set to meet again July 21 to decide whether the outbreak now constitutes a Public Health Emergency of International Concern (PHEIC). The committee first met at the end of June but decided at that time the outbreak did not qualify as a PHEIC, WHO’s highest level of alert for events that show extraordinary public health risk to other countries through international spread and require coordinated international responses.

SEXUAL HEALTH CLINICS Sexual health clinics that are on the frontlines of diagnosing many of the cases—the majority of which are occurring in men who have sex with men (MSM)—say they are preparing for the possibility that monkeypox will become endemic. The clinics are best suited to identify, test, and treat monkeypox cases, but they already are under-resourced after years of financial neglect, according to sexual health experts in the US and UK.

Although monkeypox is not historically considered to be a sexually transmitted infection (STI)—experts believe the virus is typically transmitted through skin-to-skin or close face-to-face contact—public health authorities are struggling with messaging surrounding prevention, trying to strike a balance between encouraging people to have fewer sexual partners while not stigmatizing specific communities. A study published in Eurosurveillance last week found a large proportion of semen, saliva, urine, and feces samples taken from 12 monkeypox patients in Barcelona, Spain, contained DNA of the poxvirus. Though the study suggests monkeypox transmission might be viable through sexual fluids or saliva, the presence of viral DNA does not mean infectious virus is present.

US TESTING & TREATMENT US CDC Director Dr. Rochelle Walensky this week remained optimistic that the monkeypox outbreak can be contained and defended CDC’s response, saying “dramatic progress” has been made to educate the public and healthcare providers and increase testing and vaccine access.

The CDC is working to ramp up the nation’s testing capacity, which is up to 70,000 samples per week versus 6,000 samples at the beginning of the outbreak. Aegis Science and Sonic Healthcare USA (Sonic) this week became the fourth and fifth commercial laboratories to announce monkeypox testing availability. Still, anecdotal evidence shows people continue to face major challenges to obtaining testing and treatment for monkeypox. Additionally, physicians face challenges in obtaining the smallpox treatment tecovirimat (TPOXX) for their patients due to cumbersome paperwork because the drug is not approved for monkeypox but available under expanded access Investigational New Drug (EA-IND) protocol. The US Department of Health and Human Services (HHS) and US FDA have said they are working to make the drug more easily accessible.

VACCINE SUPPLY & ACCESS As of July 15, the US government said more than 300,000 doses of the Jynneos smallpox vaccine are available to states and jurisdictions. About 156,000 of those doses had been shipped, with about 100,000 of those delivered last week. The government expects to add about 780,000 additional doses from a Bavarian Nordic facility in Denmark that recently passed US FDA inspection to the available supply by the end of July. In total, the US government has ordered nearly 7 million vaccine doses, but most of those will not be ready until late this year or next year.

Vaccine supply has been unable to keep up with demand, especially in New York City, San Francisco, and other areas. Notably, New York City announced it will only offer first doses of the 2-dose primary series until supplies increase. The move is not in line with FDA and CDC recommendations, which call for the vaccine doses to be administered 28 days apart. Both the UK and Canada are taking a similar approach to administering first doses to as many people as possible before offering second doses.

In Europe, health authorities have delivered about 25,000 vaccine doses to 6 EU member states. The European Commission announced July 18 it has ordered an additional 54,000 doses of Jynneos from Bavarian Nordic, after placing an initial order of 110,000 doses in June. Both Spain and France last week updated their vaccination strategies to include pre-exposure vaccination for high-risk populations. Portugal announced the vaccine will be offered as post-exposure prophylaxis, preferably within 4 but up to 14 days after exposure, with people who were previously vaccinated against smallpox receiving only 1 dose of Jynneos.

The world has known of the potential threat of resurgent monkeypox for decades. Now, as the number of new cases continues to rise, the international community must come up with a plan to make vaccination for monkeypox—with either the Jynneos monkeypox or ACAM2000 smallpox vaccines—widely available and avoid the inequity experienced during the COVID-19 pandemic. Additionally, increased access to diagnostic testing, treatment, and targeted education campaigns that minimize stigma are quickly needed. A determination from the WHO Emergency Committee on whether the monkeypox outbreak constitutes a PHEIC and any recommendations on how to better manage the global public health response are expected later this week.